Independent write-ups on peptide chemistry, purity testing, stability, synthesis, and the published literature — written for researchers, by people who spend their time around a lab bench.
A look at how BPC-157 has been studied in animal and in vitro models, and what the current body of preclinical literature does and doesn't tell us.
Read article →From Gila monster venom to dual and triple agonists — how four decades of incretin research produced today's most-studied peptide class.
Read article →HPLC, mass spectrometry, and Certificates of Analysis — how purity is actually measured, and what the number on a CoA does and doesn't guarantee.
Read article →Why peptides degrade, how temperature and light exposure accelerate it, and the handling practices that keep a sample research-grade.
Read article →A walkthrough of solid-phase peptide synthesis — the method behind essentially every research peptide on the market today.
Read article →Why most research peptides ship freeze-dried, and the tradeoffs a lab should weigh before choosing a lyophilized or liquid format.
Read article →What actually happens to a peptide shipment between a supplier's freezer and a lab bench, and where the cold chain most often breaks down.
Read article →A comparative look at GHRH analogs and ghrelin mimetics, and how these compounds fit into two distinct mechanistic categories.
Read article →What GHK-Cu is, how it was discovered, and what the in vitro and animal literature says about its role in tissue remodeling research.
Read article →What NAD+ does in the cell, why direct NAD+ vs. precursor compounds matters for research design, and what the literature does and doesn't establish.
Read article →How dual and triple incretin receptor agonists differ mechanistically, and what multi-receptor engagement adds compared to single-target compounds.
Read article →Chemical purity and biological safety are different questions. How endotoxin and sterility testing work, and why a high purity number doesn't answer them.
Read article →How disulfide bonds form, why they complicate solid-phase peptide synthesis, and what oxidative folding actually involves.
Read article →How the melanocortin receptor family works, and what distinguishes PT-141 and Melanotan II mechanistically within the preclinical literature.
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